In case the aorta gets rigid, stiff and inextensible on account of Diseases, which include arteriosclerosis, atherosclerosis or elastin defects (in connective tissue ailments), the heartbeat stress might be increased on account of less compliance in the aorta. See also: Central aortic blood pressure level
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A significant pulse pressure coupled with bradycardia and an irregular respiratory pattern is associated with increased intracranial tension, a problem named Cushing's triad viewed in individuals immediately after head trauma with enhanced intracranial tension.[14]
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